By Leonora Neville
Byzantine princess Anna Komnene is understood for 2 issues: plotting to homicide her brother to usurp the throne, and writing the Alexiad, an epic historical past of her father Alexios I Komnenos (1081-1118) that may be a key historic resource for the period of the 1st Crusade. Anna Komnene: the lifestyles and Work of a Medieval Historian investigates the connection among Anna's self-presentation within the Alexiad and the tale of her bloodthirsty ambition. It starts via asking why girls didn't write historical past in Anna's society, what cultural ideas Anna broke by way of doing so, and the way Anna attempted to reply to these demanding situations in her writing. some of the idiosyncrasies and surprises of Anna's Alexiad are pushed by way of her efforts to be perceived as either an exceptional historian and a great lady. those new interpretations of Anna's authorial character then spark a radical re-thinking of the normal tale which defines Anna's existence by means of the failure of her intended political objectives. the second one half this paintings stories the medieval resources with clean eyes and re-establishes Anna's basic id as an writer and highbrow instead of as a failed conspirator.
By Novartis Foundation(eds.)
This significant and interesting paintings brings jointly a high-calibre staff of specialists to debate the sensible program of genomic info to the advance of substances. fresh technological advances have ended in a quick acceleration in our skill to assemble genetic info. the whole genetic sequences are actually recognized for numerous organisms and sped up programmes are in position for sequencing many different genomes, together with human. the rate with which whole sequencing could be finished will proceed to extend as new applied sciences come on-line. In precept, the scope for constructing new diagnostic concepts and medicine is now more than at any time in human heritage, however the pathway from genetic info to usable drug is a protracted and intricate one.
This significant booklet covers such matters because the present state-of-the-art in squencing expertise, the functions of those new applied sciences to sequencing the genomes of assorted organisms, and the problem of proteomics. extra contributions care for criminal and moral implications of the recent makes use of of genetic facts, and sensible genomics from the perspective of the pharmaceutical industry.Content:
By Karen Schneider
Loving Arms examines the war-related writings of 5 British girls whose works discover the connections between gender, struggle, and story-telling. whereas no longer the 1st examine to narrate the themes of gender and struggle, it's the first inside a turning out to be physique of feedback to concentration particularly on British tradition in the course of and after international battle II.
Evoking the recognized "St. Crispin's Day" speech from Henry V after which her personal father's account of being moved to tears on V-J Day simply because he were too younger to struggle, Karen Schneider posits that the warfare tale has a far-reaching efficiency. She admits―perhaps for all of us―that such tales "had powerfully formed my awareness in methods i couldn't thoroughly resist."
How a narrative is narrated and by way of whom are concerns of no small significance. As greatly outlined and accredited, conflict tales are men's tales. If we're to listen to an "other" tale of battle, then we needs to hearken to the tales ladies inform. some of the conflict tales written by way of girls insist that warfare isn't the situation of fellows yet really the of humanity, starting with kinfolk among the sexes.
For the 5 girls whose paintings is tested in Loving Arms―Stevie Smith, Katharine Burdekin, Virginia Woolf, Elizabeth Bowen, and Doris Lessing―this latter element used to be quite suitable. Their positions as girls inside a patriarchal, militarist tradition that was once externally threatened by way of an brazenly fascist one ended in an acute ambivalence, says Schneider. although all 5 ladies perceived the warfare from considerably various views, every one in her personal manner uncovered and critiqued the seductive strength of struggle and struggle tales, with their densely interwoven tropes of masculinity and nationalism. but those writers' conflicting impulses of loyalty to England and resistance to the battle betray their ambivalence.
Loving Arms will curiosity scholars of twentieth-century British literature and tradition, gender stories, and narratology. Even at the present time, we retain an unabated love affair with the struggle tale. yet except we hearken to what the ladies needed to say fifty years in the past, we're doomed to listen to in basic terms "the standard story."
By Joann Fletcher
World-Renowned Egyptologist Dr. Joann Fletcher bargains an extraordinary examine considered one of history’s so much attention-grabbing leaders—Politician, mom, and Goddess—the mythical Cleopatra.
The topic of fable for greater than millennia, Cleopatra was once a girl of ardour, magnetism, and political genius, the final and maximum Egyptian pharaoh. during this spell binding biography, Egyptologist Joann Fletcher attracts on a wealth of newly came across info and study to bare this important girl as she actually used to be, from her first assembly with Julius Caesar to her mythical demise via snakebite.
Cleopatra the Great tells the tale of a turbulent time and the extreme girl at its heart. A polymath monarch, she used to be additionally a effective blend of traditionalist and innovator, astute adequate to gain what used to be invaluable for Egypt’s endured prosperity and sufficiently ruthless to permit not anything to face in her way.
Yet our figuring out of Cleopatra has been obscured by way of Roman propaganda, Shakespearean tragedy, and Hollywood glamour. Cleopatra the Great items jointly the pharaoh’s historical global with information about her sizeable library and notorious banquets, her relationships with either Julius Caesar and Mark Antony, and her skillful use of favor and elegance to additional her pursuits and her mystique. clever and compulsively readable, this is an remarkable biography necessary of its topic.
By Min Ding, Jehoshua Eliashberg, Stefan Stremersch
The pharmaceutical is considered one of today’s such a lot dynamic and intricate industries, related to commercialization of state of the art clinical examine, a tremendous net of stakeholders (from traders to doctors), multi-stage offer chains, fierce pageant within the race to industry, and a not easy regulatory setting. The stakes are excessive, with each one new product elevating the chance of astonishing success—or failure. around the globe sales are forthcoming $1 trillion; within the U.S. by myself, advertising for pharmaceutical items is, itself, a multi-billion buck undefined. during this quantity, the editors show off contributions from specialists world wide to seize the state-of-the-art in learn, research, and perform, and overlaying the whole spectrum of subject matters in terms of innovation and advertising, together with R&D, merchandising, pricing, branding, aggressive method, and portfolio administration. Chapters comprise such gains as:
· an intensive literature overview, together with insurance of study from fields except marketing
· an summary of ways practitioners have addressed the topic
· creation of suitable analytical instruments, akin to records and ethnographic studies
· feedback for additional study through students and students
The result's a finished, cutting-edge source that may be of curiosity to researchers, policymakers, and practitioners, alike.
By Anatole A. Klyosov, Zbigniew J. Witczak, and David Platt (Eds.)
content material: evaluate. Carbohydrates and drug layout: what's new during this e-book / Anatole A. Klyosov --
Carbohydrate therapeutics: new advancements and techniques / Zbigniew J. Witczak --
melanoma. improvement of a polysaccharide as a car to enhance the efficacy of chemotherapeutics / David Platt, Anatole A. Klyosov, and Eliezer Zomer --
DAVANAT and colon melanoma: preclinical and scientific (phase I) reviews / Anatole A. Klyosov, Eliezer Zomer, and David Platt --
Synthesis and organic task of doxo-galactose and doxo-galactomannan, new conjugates of doxorubicin with D-galactose and 1,4, [beta]-D-galactomannan / Anatole A. Klyosov ... [et al.] --
Human immunodeficiency virus. Carbohydrate-based vaccines opposed to HIV/Aids / Lai-Xi Wang --
towards a carbohydrate-based HIV-1 vaccine / Daniel Calarese ... [et al.] --
Pathogen administration. Cationic polysaccharides within the therapy of pathogenic Candida infections / Avital Mazar Ben-Josef, David Platt, and Eliezer Zomer --
New ways in synthesis and computational stories. artificial ways to comprise [alpha]-linked 2-amino-2-deoxy-D-glucopyranoside and 2-amino-2-deoxy-D-galactopyranoside residues into glycoconjugate constructions / Robert J. Kerns and Peng Wei --
Systematic synthesis of aminosugars and their stereoselective glycosylation / Jinhua Wang and Cheng-Wei Tom Chang --
functional functions of computational experiences of the glycosylation response / Dennis M. Whitfield and Tomoo Nukada.
By Christina Vella
Opposed to a richly woven ancient historical past of 2 centuries and vibrant societies, Christina Vella unfolds the compelling tale of the marital alliance among the Almonester and Pontalba households of Louisiana. Born into wealth in New Orleans in 1795, Micaela Almonester was once married into distress in France 16 years later. Intimate Enemies provides the superb real account of this resilient woman’s life—and the 3 males who most influenced its direction: her father, Andrés, an illustrious New Orleans builder in whose footsteps she finally with nice contrast; her partner's father, Xavier, who for greater than 20 years attempted to break her marriage and grab keep watch over of her fortune, ultimately capturing Micaela in violent depression; and her husband, Célestin, whom, regardless of all, she compassionately supported until eventually her demise. tailored as an opera in 2003 by way of the recent Orleans Opera, Intimate Enemies has captured the mind's eye and admiration of readers all over the place.
By T. K. Lim
quantity nine is a part of a multicompendium fit to be eaten Medicinal and Non-Medicinal crops, on crops with fit for human consumption transformed stems, roots and bulbs from Acanthaceae to Zygophyllaceae (tabular) and 32 chosen species in Alismataceae, Amaryllidaceae, Apiaceae, Araceae, Araliaceae, Asparagaceae, Asteraceae, Basellaceae, Brassicaceae and Campanulaceae intimately. This paintings is of vital curiosity to clinical practitioners, pharmacologists, ethnobotanists, horticulturists, meals nutritionists, botanists, agriculturists, conservationists, and normal public. subject matters coated comprise: taxonomy; universal/ vernacular names; foundation/ distribution; agroecology; safe to eat plant parts/uses; botany; nutritive/medicinal houses, nonedible makes use of and chosen references.
By Lisa K. Minor
The necessity to reveal objectives quicker and extra successfully, coupled with advances in parallel and multiplex chemical synthesis, has contributed to the expanding use of multiwell assays for drug discovery. The guide of Assay improvement in Drug Discovery is a reference that describes the entire armament of instruments presently on hand for acting numerous assay concepts. that includes contributions from assay builders within the pharmaceutical and seller groups, the publication provides descriptions of equipment, laboratory directions and protocols used to accomplish such tools, particular examples of every assay method, and troubleshooting instruments. The guide describes biochemical assay sessions in addition to non-class particular assay improvement for cell-based assays. It covers a variety of goal classes—including kinases, proteases, nuclear receptors, and GPCRs—and describes at present hired equipment and assay varieties, akin to radioligand binding assays, snapshot research assays, enzyme fragment complementation, and bioluminescent and fluorescent-based assays. Designed as a advisor to operating an assay from begin to end, the instruction manual of Assay improvement in Drug Discovery is a perfect bench most sensible better half for discovery researchers, laboratory managers, teachers, and different scientists enthusiastic about drug discovery screening, lead profiling, healing aim evaluate, and assay improvement and implementation within the pharmaceutical and biotechnology industries. Daniel E. Levy, editor of the Drug Discovery sequence, is the founding father of DEL BioPharma, a consulting carrier for drug discovery courses. He additionally continues a web publication that explores natural chemistry.
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