Advances in Molecular and Cellular Endocrinology, Vol. 2 by Derek LeRoith

By Derek LeRoith

Quantity 2 has keen on facets of the pituitary gland either anterior (growth hormone and prolactin receptors, and GH motion) and posterior (vasopressin) pituitary. additionally, thyroid melanoma and steroidogenic enzymes and precocious puberty are lined. eventually, the "hot subject matters" contain leptin and development issue signaling.

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Multiple cis-trans conformers of the prolactin receptor proline-rich motif(PRM) peptide detected by reverse-phase HPLC, CD, and NMR. Biochem. J. 315,833-844. A. (1997). Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse. Genes Dev. 11,167-178. , & Dusanter-Fourt, I. (1995). Interleukin-3, erythropoietin and prolactin activate a STAT5 like factor in lymphoid cells. J. Biol. Chem. 270, 15942-15945. , & Bernelli-Zazzera, A. (1994). Rapid stimulation of mitogen-activated protein kinase of rat liver by prolactin.

PLC generates diacylglycerol which in turn activates PKC. , 1989), although their role in signaling remains unknown and their substrates poorly identified (Liu, 1996). , 1995). , 1995). , 1991; Fuh and Wells, 1995). Their role remains unclear (Baumann, 1995). By protecting bound hormones from clearance, they have been proposed to increase the half-life of their ligands. , 1993). The physiological role of the short PRLR isoform is more intriguing. This isoform, which is unable to activate typical PRL signaling pathways (see above), is predominant in some tissues such as liver.

Endocrinol. 117, 131-140. C. (1994). Prolactin activates the interferon-regulated p91transcription factor and the Jak2 kinase by tyrosine phosphorylation. Proc. Natl. Acad. Sci. USA 91, 7174-7178. A. (1992). Human growth hormone and extracellular domain of its receptor: crystal structure of the complex. Science 255, 306-312. C. (1995). The proline-rich region of the growth hormone receptor is essential for Jak2 phosphorylation, activation of cell proliferation and gene transcription. Mol. Endocrinol.

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