Analysis and Purification Methods in Combinatorial Chemistry by Bing Yan

By Bing Yan

Caliber size, regulate, and development in combinatorial chemistry Combinatorial chemistry has built speedily some time past decade, with nice advances made through scientists engaged on research and purification of a big variety of compounds and the research of polymer-bound compounds. even if, ambitious demanding situations lie sooner than contemporary researcher. for instance, high-throughput research and purification applied sciences has to be additional built to make sure combinatorial libraries are "purifiable," and "drugable."

To this finish, research and Purification tools in Combinatorial Chemistry describes quite a few analytical options and structures for the improvement, validation, qc, purification, and physicochemical trying out of combinatorial libraries. a brand new quantity in Wiley's Chemical research sequence, this article has 4 components overlaying:

  • Various methods to tracking reactions on strong aid and optimizing reactions for library synthesis
  • High-throughput analytical equipment used to investigate the standard of libraries
  • High-throughput purification techniques
  • Analytical tools utilized in post-synthesis and post-purification stages

Drawing from the contributions of revered specialists in combinatorial chemistry, this finished publication presents assurance of functions of Nuclear Magnetic Resonance (NMR), liquid chromatography/mass spectrometry (LC/MS), Fourier rework Infrared (FTIR), micellar electrokinetic chromatography (MEKC) applied sciences, in addition to different analytical recommendations.

This eminently priceless quantity is an important addition to the library of scholars and researchers learning or operating in analytical chemistry, combinatorial chemistry, medicinal chemistry, natural chemistry, biotechnology, biochemistry, or biophysics.

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Reagents and conditions: (i) DIEA, 3-amino-propionic acid ethyl ester, DMF, 25°C. 9.

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