By Tung-Hu Tsai
Discover new and rising purposes for microdialysis in drug evaluation
Microdialysis is a hugely invaluable sampling device that may be utilized in vivo to degree loose, unbound analyte concentrations situated in interstitial and extracellular areas. This booklet explores the complete variety of medical functions for microdialysis, concentrating on its use in numerous organ and tissue structures for pharmacokinetic and pharmacodynamic reports. Readers achieve an entire figuring out of the underlying technology of microdialysis, present recommendations and practices, in addition to its many functions in pharmaceutical research.
Applications of Microdialysis in Pharmaceutical technological know-how starts off with an creation to uncomplicated rules after which covers analytical concerns, pharmacodynamic and pharmacokinetic experiences, medical facets, and distinctive purposes. subject matters include:
Role of microdialysis in drug improvement, together with an important sampling issues and functions for worried procedure diseases
Continuous dimension of glucose concentrations in diabetics
Applications for scientific overview and simple study on organ platforms, together with tracking exogenous and endogenous compounds within the lungs
Pharmacokinetic and pharmacodynamic evaluate of anticancer drugs
Comparison of microdialysis with imaging techniques to judge in vivo drug distribution
Special purposes of microdialysis in reports of mobilephone tradition assays, drug-drug interactions, and environmental monitoring
Throughout the publication, readers will locate easy types that make clear advanced strategies and easy-to-follow examples that consultant them via key purposes in pharmaceutical examine. in brief, this e-book allows pharmaceutical researchers to take complete good thing about microdialysis thoughts for the preclinical and medical review of gear and lots more and plenty extra.
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Extra info for Applications of Microdialysis in Pharmaceutical Science
1999). Use of intravenous microdialysis to monitor changes in serotonin release and metabolism induced by cisplatin in cancer patients: comparative effects of granisetron and ondansetron. Journal of Pharmacological and Experimental Therapeutics, 291, 960–966. , Dabrosin, C. (2003). Tamoxifen inhibits secretion of vascular endothelial growth factor in breast cancer in vivo. Cancer Research, 63, 8742–8748. S. (2001). Microdialysis and response during regional chemotherapy by isolated limb infusion of melphalan for limb malignancies.
H. (2003). Assaying protein unbound drugs using microdialysis techniques. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 797, 161–173. K. (1996). Concentration-dependent plasma protein binding of flurbiprofen in the rat: an in vivo microdialysis study. Pharmaceutical Research, 13, 18–22. , Derendorf, H. (2008). Effect of protein binding on the pharmacological activity of highly bound antibiotics. Antimicrobial Agents and Chemotherapy, 52, 3994–4000. A.
The rationale for microdialysis sampling in oncology drug development is restricted by the fact that most antineoplastic drugs act within cells, and the relationship between extracellular drug concentrations and intracellular drug levels remains unknown. Nevertheless, as noted above, this drawback could be overcome by employing an attractive approach based on simultaneous study of drug distribution by microdialysis and PET . , 5-FU) require intracellular enzymatic conversion in order to exert their cytotoxic activity.