Bionanomaterials for Skin Regeneration by Mihaela D. Leonida, Ish Kumar

By Mihaela D. Leonida, Ish Kumar

This ebook supplies a concise assessment of bionanomaterials with functions for epidermis regeneration. the benefits and demanding situations of nanoscale fabrics are lined intimately, giving a easy view of the outside constitution and stipulations that require transdermal or topical functions. scientific purposes, reminiscent of wound therapeutic, take care of burns, dermis ailment, and beauty care, resembling getting older of the surface and photodamage, and the way they take advantage of bionanomaterials, are defined intimately. a last bankruptcy is dedicated to the moral and social matters with regards to using bionanomaterials for dermis regeneration. this is often a terrific ebook for researchers in fabrics technological know-how, scientific scientists really good in dermatology, and beauty chemists operating in formulations. it may additionally function a reference for nanotechnologists, dermatologists, microbiologists, engineers, and polymer chemists, in addition to scholars learning in those fields.

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Neither UVA nor UVB can interact with molecular oxygen directly. However, epidermal proteins can absorb UVB radiation via excitation of aromatic amino acids like tryptophan, tyrosine or of disulfide bonded cysteine indirectly producing reactive oxygen species (ROS) responsible for various damages [45]. Also DNA/RNA bases can absorb UVB radiation, which can further lead to various mutations, arrest of the cell cycles, and apoptotic death of the cells. Intrinsic aging is associated with decreased replication ability of the cells and increased degradation of the ECM [46].

A drug reservoir is placed on the skin, the electrode with the same charge as the drug is placed on the top of that reservoir and another electrode with opposite charge is placed somewhere else on the skin to close the circuit. Application of a small current enables the charged penetrants to get inside the skin. Currently, Sumatriptan (Fig. 1, compound 19) has been approved to treat migraine patients using iontophoresis as an enhancement method [3, 24]. Electroosmosis is another similar technique used to enhance penetration of uncharged and larger molecules.

J Invest Dermatol 124:898–905 49. Dai G, Freudenberger T, Zipper P, Melchior A, Grether-Beck S, Rabausch B, De GJ, Twarock S, Hanenberg H, Homey B, Krutmann J, Reifenberger J, Fischer JW (2007) Chronic ultraviolet B irradiation causes loss of hyaluronic acid from mouse dermis because of down-regulation of hyaluronic acid synthases. Am J Pathol 171:1451–1461 50. Birkedal-Hansen H (1987) Catabolism and turnover of collagens: collagenases. Methods Enzymol 144:140–171 51. Krieg T, Hein R, Hatamochi A, Aumailley M (1988) Molecular and clinical aspects of connective tissue.

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