Biopharmaceutics Modeling and Simulations: Theory, Practice, by Kiyohiko Sugano

By Kiyohiko Sugano

A entire creation to utilizing modeling and simulation courses in drug discovery and development

Biopharmaceutical modeling has turn into necessary to the layout and improvement of latest medicinal drugs. Influencing key points of the improvement approach, together with drug substance layout, formula layout, and toxicological publicity evaluate, biopharmaceutical modeling is now visible because the linchpin to a drug's destiny luck. And whereas there are various commercially on hand software program courses for drug modeling, there has no longer been a unmarried source guiding pharmaceutical pros to the particular instruments and practices had to layout and try secure drugs.

A advisor to the fundamentals of modeling and simulation courses, Biopharmaceutics Modeling and Simulations bargains pharmaceutical scientists the keys to knowing how they paintings and are utilized in growing medicinal drugs with wanted medicinal homes. starting with a spotlight at the oral absorption of gear, the booklet discusses:

  • The primary dogma of oral drug absorption (the interaction of dissolution, solubility, and permeability of a drug), which kinds the root of the biopharmaceutical category process (BCS)
  • The proposal of drug concentration
  • How to simulate key drug absorption processes
  • The physiological and drug estate facts used for biopharmaceutical modeling
  • Reliable practices for reporting results

With over 2 hundred figures and illustrations and a peerless exam of all of the key points of drug research?including operating and analyzing types, validation, and compound and formula selection?this reference seamlessly brings jointly the confirmed useful methods necessary to constructing the secure and powerful medicinal drugs of tomorrow.

Content:
Chapter 1 creation (pages 1–9):
Chapter 2 Theoretical Framework I: Solubility (pages 10–32):
Chapter three Theoretical Framework II: Dissolution (pages 33–63):
Chapter four Theoretical Framework III: organic Membrane Permeation (pages 64–121):
Chapter five Theoretical Framework IV: Gastrointestinal Transit types and Integration (pages 122–159):
Chapter 6 body structure of Gastrointestinal Tract and different management websites in people and Animals (pages 160–205):
Chapter 7 Drug Parameters (pages 206–265):
Chapter eight Validation of Mechanistic versions (pages 266–321):
Chapter nine Bioequivalence and Biopharmaceutical class approach (pages 322–339):
Chapter 10 Dose and Particle measurement Dependency (pages 340–346):
Chapter eleven allowing Formulations (pages 347–378):
Chapter 12 nutrition impression (pages 379–411):
Chapter thirteen Biopharmaceutical Modeling for Miscellaneous circumstances (pages 412–429):
Chapter 14 Intestinal Transporters (pages 430–451):
Chapter 15 approach in Drug Discovery and improvement (pages 452–458):
Chapter sixteen Epistemology of Biopharmaceutical Modeling and strong Simulation perform (pages 459–463):

Show description

Read Online or Download Biopharmaceutics Modeling and Simulations: Theory, Practice, Methods, and Applications PDF

Best pharmacy books

Statistical Design and Analysis of Stability Studies (Chapman & Hall Crc Biostatistics Series)

The united states meals and Drug Administration's report back to the state in 2004 and 2005 indicated that one of many best purposes for drug remember used to be that balance information didn't aid present expiration dates. Pharmaceutical businesses behavior balance reviews to represent the degradation of drug items and to estimate drug shelf existence.

Green Techniques for Organic Synthesis and Medicinal Chemistry

Content material: bankruptcy 1 eco-friendly Toxicology (pages 1–23): Nicholas D. AnastasChapter 2 eco-friendly Chemistry and the Pharmaceutical (pages 25–32): Amy S. Cannon, Joseph L. Pont and John C. WarnerChapter three Environmental technology; Guiding eco-friendly Chemistry, production, and Product suggestions (pages 33–66): Richard T.

Lipid Nanoparticles: Production, Characterization and Stability

​What are lipid nanoparticles? How are they dependent? How are they shaped? What recommendations are top to symbolize them? How nice is their capability as drug supply structures? those questions and extra are replied during this entire and hugely readable paintings on lipid nanoparticles. This paintings units out to supply the reader with a transparent and comprehensible realizing of the present practices in formula, characterization and drug supply of lipid nanoparticles.

Compliance Handbook for Pharmaceuticals, Medical Devices, and Biologics

The paintings of compliance is a craft very similar to that of a chippie who learns to paintings with several types of wooden and designs. Ours is an wrought with changes. whereas the laws that govern FDA-regulated industries are proscribed, how the rules are interpreted and utilized rather depends upon adventure and the way good one has mastered the craft of compliance.

Extra resources for Biopharmaceutics Modeling and Simulations: Theory, Practice, Methods, and Applications

Example text

For low permeability and/or low solubility drugs, colonic absorption is usually negligible because of the small absorptive surface area, small fluid volume, solidification of the fluid, lack of bile micelles, etc. 4 DRUG AND API FORM The patterns of oral drug absorption can be also categorized from the viewpoint of the properties of the drug molecule and API solid form. A drug can be categorized as undissociable or dissociable ones. The dissociable drug is then further categorized as acid, base, or zwitterions.

Eur. J. Pharm. , 29, 294–305. 16. A. (2010). A modified physiological BCS for prediction of intestinal absorption in drug discovery. Mol. , 7(5), 1478–1487. 17. , Olsson, U. (2006). Amorphous drug nanosuspensions. 2. Experimental determination of bulk monomer concentrations. Langmuir, 22, 911–916. 18. , Olsson, U. (2008). Nucleation and crystal growth in supersaturated solutions of a model drug. J. , 325, 404–413. 19. S. (1994). A simple “back of the envelope” method for estimating the densities and molecular volumes of liquids and solids.

3. 47~52 Eq. 27 Dissociation constant (K ) Equations 0 Sh Lipophilicity (P ) Constant, depends on GI position API p,API Eq. 30 Crystal energy X Eq. 17 Dissolution Particle growth Eq. 3 Ssurface X Permeation Eq. 1 dissolv K a a Size (MW) Eq. 3 D mono Eq. 1 Eq. 8 D eff Eq. 24 Eq. 36 Eq. 34 Eq. 1 Eq. 31 P para Eq. 28 Ptrans P UWL P Eq. 2 Peff Eq. 1 kperm ep Network of equations consisting of the GUT framework. Total Concentration Total concentration of a drug (Ctot ) is the amount of a drug substance in a fluid, regardless of the substance being undissolved solid or dissolved molecules.

Download PDF sample

Rated 4.47 of 5 – based on 42 votes