By N. Ghista Dhanjoo, Eddie Yin-kwee Ng
For the 1st time, this worthwhile ebook exhibits how cardiac perfusion and pumping could be quantified and correlated. Self-contained and unified in presentation, the reasons within the compendium are precise adequate to catch the reader s interest and entire sufficient to supply the historical past fabric to discover additional into the topic. Mathematically rigorous and clinically orientated, the booklet is an incredible source for biomedical engineers, cardiologists, cardiac surgeons and clinicians. for college students, it really is an incredible textbook for senior-level classes in cardiovascular engineering.
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Additional info for Cardiac perfusion and pumping engineering
Matsumoto, M. Goto, H. Tachibana, Y. Ogasawara, K. Tsujioka, and F. Kajiya, Microheterogeneity of myocardial blood ﬂow in rabbit hearts during normoxic and hypoxic states, American Journal of Physiology 270 (1996) H435–441. June 6, 2007 6:7 WSPC/SPI-B421 Cardiac Perfusion and Pumping Engineering ch01 Physiomics of Myocardial Perfusion and Pumping 15 14. T. Matsumoto, J. Ebata, H. Tachibana, M. Goto, and F. Kajiya, Transmural microcirculatory blood ﬂow distribution in right and left ventricular free walls of rabbits, American Journal of Physiology 277 (1999) H183–191.
For comparison, in the normal heart physical exercise results in heart rate increase and endogenous catecholamine release to increase the blood volume ejected by LV per minute and myocardial contractile function. At the same time, LV stroke work is close to the value seen during steady-state conditions. In the experimental model, however, contractility reserve could be introduced to come from outside. One could add, for example, a positive inotropic agent (say, calcium or adrenaline) to the perfusion bath that surrounds the muscle.
Kajiya, O. Hiramatsu, T. Yada, E. Toyota, T. Kiyooka, S. Mohri, J. Shimizu, Y. Ogasawara, and F. Kajiya, Physiomic approach to biomechanics of coronary microcirculation, Journal of Mechanics in Medicine and Biology 5, 1 (2005) 1–9. ru 1. 5,17 Meanwhile, the signiﬁcance of inhomogeneity for the normal heart has not yet been clariﬁed. 9,18–20 In physical terms, however, it is diﬃcult to imagine that the performance of an inhomogeneous muscular pump could be higher than that of a homogeneous one, such as a sphere.