Chromatography of Pharmaceuticals. Natural, Synthetic, and by Satinder Ahuja

By Satinder Ahuja

content material: Chromatography and pharmaceutical research / Satinder Ahuja --
Chromatography and new drug improvement / Satinder Ahuja --
exchange options for research of prescribed drugs / John A. Adamovics and Kimberly Shields --
Ruggedness of impurity determinations in prescribed drugs : high-performance liquid chromatography research with ultraviolet detection / M.P. Newton, John Mascho, and Randy J. Maddux --
High-performance liquid chromatography in pharmaceutical improvement of antibiotic items / L.J. Lorenz --
fuel chromatography and pharmaceutical analyses / Harold M. McNair and Ketan M. Trivedi --
fuel chromatography and mass spectrometry of Erythrina alkaloids from the foliage of genetic clones of 3 Erythrina species / Lori D. Payne and Joe P. Foley --
constructing stereoselective high-performance liquid chromatographic assays for pharmacokinetic reviews / Irving W. Wainer --
Direct enantiomeric separation and research of a few aromatase inhibitors on cellulose-based chiral desk bound stages / Hassan Y. Aboul-Enein --
Chromatographic research of host-cell protein impurities in prescribed drugs derived from recombinant DNA / Donald O. O'Keefe and Mark L. Will --
Binding proteins in improvement of online postcolumn response detection structures for liquid chromatography / Minas S. Barbarakis and Leonidas G. Bachas --
decision of a brand new oral cephalosporin in organic fluids : liquid chromatographic, ultraviolet, and mass spectrometric tools / Hwai-Tzong Pan, Pramila Kumari, and Chin-Chung Lin --
medicinal drugs and metabolites in organic fluids : automatic research by means of laboratory robotics / Linda A. Brunner --
Preparative separations of glycerophospholipids through high-performance liquid chromatography / J.V. Amari and P.R. Brown --
Small-molecule pharmaceutical separations by way of capillary electrophoresis : procedure improvement and manipulation of selectivity / Michael E. Swartz and John VanAntwerp.

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Additional resources for Chromatography of Pharmaceuticals. Natural, Synthetic, and Recombinant Products

Example text

Aztreonam shows only a slight decrease in retention as depicted in Figure 4. For neutral compounds no apparent changes in retention are observed (25). These observations are consistent with an ionexchange mechanism where the k values are strongly dependent on the concentration of cations in the eluent due to the competitive displacement from the ion exchange sites. At neutral eluent pH's the increase in the ionic strength has shown to change the selectivity of some basic analytes. The change in selectivity is believed to be due to the presence of a portion of each base in the nonprotonated forms, particularly at a pH near their pKa (35).

1990, 521, 19. ; ACS Symposium Series; American Chemical Society: Washington, DC, 1992. ch004 High-Performance Liquid Chromatography Analysis with Ultraviolet Detection M. P. Newton, John Mascho, and Randy J. , Zebulon, NC 27597 The use of relative response factors i s a good means to obtain weight percent impurity values when employing HPLC analysis with UV detection. The ruggedness of the relative response factor for a given reference and impurity compound i s inversely proportional to the difference i n shape and slope of the respective UV curves near the analytical wavelength.

Liq. Chromatogr. 1991, 14, 253. 23. Shi, R. J. ; Bonet, L. Z. and Lin, E. T. J. Chromatogr. 1986, 377, 399. 24. ;Stoney, G. C. A and Holt, D. W. J. Chromatogr. , 1979, 16, 271. ; ACS Symposium Series; American Chemical Society: Washington, DC, 1992. ch003 3. ADAMOVICS AND SHIELDS Analysis of Pharmaceuticals 25. L. and Stewart, J. T. J. Liq. Chromatogr. 1989, 12, 3231. 26. Shi, R. J. ; Gee, W. ; Williams, R. L. and Lin, E. T. J. Liq. , 1987, 10, 3101. 27. , Lin, E. , Theoharidos, A. D. and Fleckenstein, L.

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