Class 2 Transferases: EC 2.7.11.1–2.7.11.16 by Professor Dietmar Schomburg, Dr. Ida Schomburg, Dr. Antje

By Professor Dietmar Schomburg, Dr. Ida Schomburg, Dr. Antje Chang (eds.)

Springer instruction manual of Enzymes offers information on enzymes sufficiently good characterised. It deals concise and entire descriptions of a few 5,000 enzymes and their software parts. facts sheets are prepared of their EC-Number series and the volumes themselves are prepared in accordance with enzyme classes.

This new, moment variation displays enormous growth in enzymology: many enzymes are newly categorised or reclassified. each one access is correlated with references and a number of resource organisms. New datafields are created: software and engineering (for the houses of enzymes the place the series has been changed). the entire volume of fabric inside the guide has greater than doubled in order that the whole moment variation includes 39 volumes in addition to a Synonym Index. furthermore, beginning in 2009, all newly labeled enzymes are handled in complement Volumes.

Springer guide of Enzymes is a perfect resource of data for researchers in biochemistry, biotechnology, natural and analytical chemistry, and meals sciences, in addition to for medicinal applications.

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Additional info for Class 2 Transferases: EC 2.7.11.1–2.7.11.16

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E. g. 1 Non-specific serine/threonine protein kinase P ADP + phosphorylated RSRSRSRSRSRSPPPVSK S ATP + S6 protein of the 40s ribosomal subunit <53> (<53> the mitogenactivated protein kinase plays a central role in the control of mRNA translation. ) [471] P ADP + phosphorylated SIV/17E-Fr Nef protein S ATP + SR protein <225, 226, 227, 228, 229, 230, 231> (<225> dsk1 protein may play an important role in mitotic control by altering cellular location, degree of phosphorylation and kinase activity [311]; <231> enzyme acts as a corepressors for homeodomain transcription factors [320]; <231> enzyme regulates the activation and adhesion of T cells.

Alterations of this complex expression pattern can be responsible for the mental status impairment observed in myotonic dystrophy patients [96]; <70> enzyme may have a role in the development of mental symptoms in severe cases of myotonic dystrophy [98]; <69> the enzyme is highly regulated at the transcriptional level by glucocorticoid hormones [95]; <69> SGK is a component of the phosphoinositide 3 (PI 3)-kinase signaling pathway [92]; <82> enzyme is important for cell growth [113]; <65> mutations in the ribosomal S6 kinase (Rsk-2) gene are associated with Coffin-Lowry syndrome, an X-linked disorder characterized by facial dysmorphism, digit abnormalities and severe psychomotor retardation [82,83,84]; <79> ribosomal S6-kinase RSK4 is commonly deleted in patients with complex X-linked mental retardation, RSK4 plays a role in normal neuronal development.

372] P ADP + ? e. g. 1 Non-specific serine/threonine protein kinase P ADP + phosphorylated RSRSRSRSRSRSPPPVSK S ATP + S6 protein of the 40s ribosomal subunit <53> (<53> the mitogenactivated protein kinase plays a central role in the control of mRNA translation. ) [471] P ADP + phosphorylated SIV/17E-Fr Nef protein S ATP + SR protein <225, 226, 227, 228, 229, 230, 231> (<225> dsk1 protein may play an important role in mitotic control by altering cellular location, degree of phosphorylation and kinase activity [311]; <231> enzyme acts as a corepressors for homeodomain transcription factors [320]; <231> enzyme regulates the activation and adhesion of T cells.

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