DHEA and the brain by Morfin, Robert

By Morfin, Robert

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R. (2001) The effects of ginseng, ephedrine, and caffeine on cognitive performance, mood and energy. Nutrition Reviews, 59, 91–102. , Holsboer, F. (1999) Differential behavioural effects of chronic infusion of CRH 1 and CRH 2 receptor antisense oligonucleotides into the rat brain. Journal of Psychiatric Research, 33, 153–163. , Schallert, T. (1988) Aging and atropine effects on spatial navigation in the Morris Water Task. Behavioral Neuroscience, 102, 621–634. , Fisone, G. (2002) Involvement of darpp-32 phosphorylation in the stimulant action of caffeine.

The various traditional and nontraditional methods for extracting bioactive ingredients from herbs and plant materials have recently been reviewed by Vinatoru et al. (1997, 2001), and the procedures for extracting antitumor polysaccharides from medicinal plants has been described by Wong et al. (1994). The task of identifying the active compound can become complicated if the compound is unstable when subjected to the physical and chemical procedures used for extraction or if bioactivity results from a combination of factors and loss of one of these factors results in a significant reduction in functionality.

If there is no information available on the nature of the active compound in an ingredient or supplement being tested, it may be difficult to develop an appropriate chemical assay that correlates with the bioactivity of the material. In this situation, the behavioral test being used to demonstrate the performance enhancement also may have to be used as a bioassay. For example, different sources of garlic have been tested for their anticarcinogenic effect in a rat model of chemically induced mammary tumors (Ip and Lisk, 1994).

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